WORLD OF REPRODUCTIVE BIOLOGY: Histone-Eating Machine Primes Sperm DNA

WORLD OF REPRODUCTIVE BIOLOGY: Progesterone and Endocannabinoid Interaction Alters Sperm Activation

A recent study in Science finds that α/β-hydrolase domain-containing protein 2 (ABHD2) is a novel nongenomic progesterone receptor that holds the CatSper cation channel open while progesterone elevates sperm cytoplasmic calcium ion (Ca) levels and triggers sperm hyperactive motility. ABHD2 functions as a lipid hydrolase, breaking down arachidonoylglycerols (2-AG/1AG)—endocannabinoid components ...

Cranes of the World: 5. Comparative Reproductive Biology

Consequences of sperm DNA fragmentation for assisted reproductive technology

The possession of offspring is the most important human biological goal, which conditions the survival of the human species. The problem of the lack of offspring is a phenomenon concerning approximately 15% of married couples in Poland. In a half of the cases, the causative agent is the male factor infertility problem. It is considered that in approximately 20% of patients with idiopathic infer...

Headliners: Reproductive Health: Sperm DNA Changes as Men Age

as the site for the newly established Division of Environmental Health Sciences , the area was probably not foreseen as a hub for companies, institutions, and government agencies working on issues related to environmental health. Then, just two years later, the Division of Environmental Health Sciences was elevated to institute status to form the NIEHS. Since that time, the area now known as Re...

BINDING OF THE ANTITUMOR DRUG ADRIAMYCIN TO DNA-HISTONE COMPLEXES

Isotherms of the binding of the anthracycIine antibiotic, adriamycin (adriblastin), to DNA histone complexes was studied by means of spectroscopic analysis. The results indicated that: (a) binding of adriamycin to histones reduced the interaction of histones with DNA, (b) binding of the drug to DNA did not change the binding affinity of histone to DNA and, (c) in the explored binding range...